Symposia/Workshop programme

 

Role of the t-tubules in subcellular modulation of cardiac excitation-contraction coupling

Synopsis

 

Organised by

Clive Orchard (University of Bristol, UK) and Fabien Brette (University of Manchester, UK)

 

Location *

TBC

 

0845

Welcome and Introduction Clive Orchard

0900

Christian Soeller (University of Auckland, New Zealand)
Probing structure and function of the cardiac transverse tubular system with high-resolution optical microscopy

0930

0930– 0945 John Bridge (University of Utah Health Sciences Center, USA)
Confocal imaging of t-tubules and ryanodine receptors suggest that local control theories cannot explain excitation-contraction coupling in heart

0945– 1000 Fabien Brette (University of Manchester, UK)
Function of t-tubules: insights from detubulation technique

1000

Long-Sheng Song (University of Iowa, USA)
T-tubular remodeling and Ca2+ instability in cardiomyopathies

1030

Coffee

1100

Ole Sejersted (University of Oslo, Norway)
Functional consequences of altered t-tubule organisation in cardiac disease

1130

Karin Sipido (University of Leuven, Belgium)
Reduced synchrony of Ca release from the sarcoplasmic reticulum in chronic ischemia

 

Synopsis

Contraction of the heart is caused by contraction of muscle cells within the heart. The muscle cells principally responsible for pumping blood around the body have tubules (t-tubules) that open at the outer surface of the cell and have complex ramifications within the cell. The proteins that initiate and regulate cell contraction are located predominantly in these tubules, which therefore form a specialized region that plays a central role in contraction of the cell, and hence the heart. This symposium will present recent advances in our knowledge of t-tubule function in normal and failing heart.

 

Symposia Location Key

LT 1 Babbage Lecture Theatre (New Museums Site)
LT 2 Cockcroft Lecture Theatre (New Museums Site)
LT 3 Main Physiology Lecture Theatre (Downing Site)
LT 4 Main Anatomy Lecture Theatre (Downing Site)
LT 5 Biffin Lecture Theatre (Downing Site)
LT 6 Physiology Lecture Theatre 3 (Downing Site)
LT 7 Arts School Room B (New Museums Site)
LT 8 Arts School Room C (New Museums Site)