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Symposia/Workshop programme
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Hypothalamic regulation of mammalian fertility
Synopsis 
Organised by
Bill Colledge (University of Cambridge, UK)
Location
TBC
8:45 |
Bill Colledge (University of Cambridge,
UK) |
9:00 |
Kevin Murphy (Imperial College,
London) |
9:30 |
Nicolas de Roux (INSERM, Paris) |
10:00 |
Bill Colledge (University of Cambridge,
UK) |
10:30 |
Coffee |
11:00 |
Manual Tene-Sempere (University of
Cordoba, Spain) |
11:30 |
Tony Plant (University of Pittsburgh) |
Synopsis
Sexual maturation (puberty) and adult mammalian fertility are centrally controlled by the hypothalamus which secretes gonadotropin releasing hormone (GnRH) to activate the downstream pituitary-gonadal axis. While GnRH secretion is highly regulated by several factors including sex steroids, the key molecules responsible for activation of GnRH secretion at puberty have remained elusive. Recently, however a novel hypothalamic signalling pathway has been identified that is an essential gatekeeper of GnRH release. Peptides (kisspeptins) encoded by the Kiss1 gene bind to a G-protein coupled receptor (GPR54) to regulate GnRH secretion and entry into puberty. Human and mouse genetic mutations in GPR54 cause sterility. Alterations in the expression pattern of Kiss1 provide mechanistic insights into how sex steroids may regulate GnRH release and how this system might integrate with other physiological systems to regulate fertility. This symposium brings together experts in the field to provide a comprehensive overview of the genetic, molecular, physiological and clinical aspects of the role of the hypothalmus in the control of mammalian reproduction.
Symposia Location Key
| LT 1 | Babbage Lecture Theatre | (New Museums Site) |
| LT 2 | Cockcroft Lecture Theatre | (New Museums Site) |
| LT 3 | Main Physiology Lecture Theatre | (Downing Site) |
| LT 4 | Main Anatomy Lecture Theatre | (Downing Site) |
| LT 5 | Biffin Lecture Theatre | (Downing Site) |
| LT 6 | Physiology Lecture Theatre 3 | (Downing Site) |
| LT 7 | Arts School Room B | (New Museums Site) |
| LT 8 | Arts School Room C | (New Museums Site) |