Symposia/Workshop programme


 

Mouse models for human epithelial disease: novel insights and new horizons

Synopsis

 

Organised by

Peying Fong (Kansas State University College of Veterinary Medicine, USA), Paul Sharp (King's College London, UK) and Mike Gray (University of Newcastle upon Tyne, UK)

 

Location

TBC

0845

Welcome and Introduction - Peying Fong (Kansas State University,
USA)

0900

Marcus Mall (University of Heidelberg, Germany)
Role of ENaC in the pathogenesis and as a therapeutic target for cystic fibrosis

0930

Ursula Seidler (Hannover Medical School, Germany)
New models for intestinal electrolyte transport regulation

1000

Craig Smith (University of Manchester, UK)
Urea transporters

1030

Coffee

1100

Michelle Boone (Radboud Universiteit Nijmegen, The Netherlands)
Congenital Nephrogenic Diabetes Insipidus: what can we learn from mouse models

1130

Sandra Guggino (The Johns Hopkins University School of Medicine, USA)
Dent's disease from endocytosis to renal failure

 

Synopsis

Epithelia perform important and diverse functions, such as regulating the composition and volume of circulating fluids, absorbing nutrients, and maintaining a barrier against pathogens. These functions require the coordinated action of proteins that move substances between the body and the outside world. Mutations in the genes that encode such transport proteins compromise epithelial function, and lead to a number of important human diseases. Although much is now known about how mutant transport proteins (mis)behave in isolated systems these diseases often result in multiple systemic disturbances which cannot be easily explained or anticipated. Transgenic mouse models for such human diseases provide powerful tools to aid our understanding of the complex and varied aetiologies of these conditions, and are an important platform for the development of effective treatments or cures. This symposium aims to provide up-to-date overviews of the current state of knowledge, the hurdles to overcome, and both the achieved and anticipated advances resulting from using these model organisms.

 

Symposia Location Key

LT 1 Babbage Lecture Theatre (New Museums Site)
LT 2 Cockcroft Lecture Theatre (New Museums Site)
LT 3 Main Physiology Lecture Theatre (Downing Site)
LT 4 Main Anatomy Lecture Theatre (Downing Site)
LT 5 Biffin Lecture Theatre (Downing Site)
LT 6 Physiology Lecture Theatre 3 (Downing Site)
LT 7 Arts School Room B (New Museums Site)
LT 8 Arts School Room C (New Museums Site)